Cristiano Ronaldo is the obvious captain for Tuesday's match between AC Milan and Juventus, but RotoWire's Juan Pablo Aravena sees a number of other solid contributors.
Paris Saint-Germain have nothing to play for Wednesday, but they could still start their elite attackers, including a recently back from injury Neymar.
Bayern Munich and Paris Saint-Germain could be popular stacks if they run out their regular starters Wednesday, which means Kylian Mbappe should be on plenty of fantasy radars.
Edin Dzeko will be the key man up front Wednesday for Roma, who may need to feed their star striker if they fall behind early.
Paris Saint-Germain are favored at home against Manchester United on Wednesday, and RotoWire's Adam Zdroik makes the case for rostering Marquinhos despite his defensive position.
Manchester United host Paris Saint-Germain on Tuesday, and RotoWire's Andrew Laird believes Paul Pogba could be the highest-owned player on the slate.
Neymar is likely to get plenty of attention because PSG are big favorites away to Crvena Zvezda on Tuesday, but RotoWire's Adam Zdroik makes the case for pivoting to Kylian Mbappe.
Predicting saves and clean sheets isn't the easiest part of building a fantasy Premier League team, but that doesn't stop RotoWire's Andrew Laird from trying.
Robert Lewandowski and Cristiano Ronaldo are likely to get plenty of attention on Tuesday's two-game slate, but Evan Morter says fantasy players shouldn't ignore Gonzalo Higuain.
Tuesday's two-game slate offers one clear favorite, which means plenty of fantasy players will be rostering Sergio Aguero.
Paulo Dybala has 10 goals in six Serie A matches this season, and his share of set pieces makes him one of the best fantasy options available on Wednesday's seven-game slate.
Miralem Pjanic's role for Juventus allows him to pick up fantasy points all over the pitch, giving him a solid floor Wednesday against Olympiacos.
Manchester United are heavily favored over FC Basel on Tuesday, and fantasy owners could get plenty of points out of midfielder Henrik Mkhitaryan.
Wales really need all three points Tuesday against Moldova, which means they'll be relying heavily on the play of Gareth Bale.
While plenty of fantasy managers are likely to focus on the two sides that need to make up deficits, Andrew Laird says don't forget about why they are behind.